23/08: Hair loss in alopecia areata
J Am Acad Dermatol. 2010, 62(2):177-
Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.
Alkhalifah A, Alsantali A, Wang E, McElwee KJ,
Abstract
Alopecia areata (AA) is an autoimmune disease that presents as nonscarring hair loss, although the exact pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer clinical variants have been described. The presence of AA is associated with a higher frequency of other autoimmune diseases. Controversially, there may also be increased psychiatric morbidity in patients with AA. Although some AA features are known poor prognostic signs, the course of the disease is unpredictable and the response to treatment can be variable. Part one of this two-part series on AA describes the clinical presentation and the associated histopathologic picture. It also proposes a hypothesis for AA development based on the most recent knowledge of disease pathogenesis. .....
Hair loss treatment hair regroowth
Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.
Alkhalifah A, Alsantali A, Wang E, McElwee KJ,
Abstract
Alopecia areata (AA) is an autoimmune disease that presents as nonscarring hair loss, although the exact pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer clinical variants have been described. The presence of AA is associated with a higher frequency of other autoimmune diseases. Controversially, there may also be increased psychiatric morbidity in patients with AA. Although some AA features are known poor prognostic signs, the course of the disease is unpredictable and the response to treatment can be variable. Part one of this two-part series on AA describes the clinical presentation and the associated histopathologic picture. It also proposes a hypothesis for AA development based on the most recent knowledge of disease pathogenesis. .....
Hair loss treatment hair regroowth
21/08: Hair loss Regrowth
J Eur Acad Dermatol Venereol. 2010 Jul 13. [Epub ahead of print]
Lipid peroxidation/antioxidant activity in patients with hair loss in alopecia areata.
Abdel Fattah NS, Ebrahim AA, El Okda ES.
Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Abstract Background Aetiopathogenesis of alopecia areata (AA) is not fully understood and many factors have been assumed. Oxidant/antioxidant disequilibrium has been proposed with controversies between results. Objectives The aim of this study was to determine lipid peroxidation/antioxidant activity in patients with AA and to determine its clinical significance. Methods Fifty non-obese patients with AA and 50 age-, gender- and body mass index-matched controls (25 patients with severe grade acne vulgaris representative of an oxidative stress condition and 25 healthy volunteers), were included. Levels of malondialdehyde (MDA), indicator of lipid peroxidation and antioxidant activity of superoxide dismutase (SOD), were spectrophotometrically measured in blood from all subjects and in scalp tissues from 10 patients with AA. Results No significant differences in MDA levels and SOD activity existed between patients with AA and those with acne. However, significantly higher MDA levels and lower SOD activity were found in patients with AA compared with healthy controls. Within patients with AA, lipid peroxidation/antioxidant parameters showed significant differences with disease duration, pattern and extent of lesions. Significant positive correlations also existed between tissue and blood SOD activity and between tissue and blood MDA levels of the 10 studied patients with AA. Conclusions Increased lipid peroxidation and defective SOD activity exist in patients with AA. Addition of drugs with antioxidative effects seems to be valuable in treatment.
hair loss blog
Lipid peroxidation/antioxidant activity in patients with hair loss in alopecia areata.
Abdel Fattah NS, Ebrahim AA, El Okda ES.
Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Abstract Background Aetiopathogenesis of alopecia areata (AA) is not fully understood and many factors have been assumed. Oxidant/antioxidant disequilibrium has been proposed with controversies between results. Objectives The aim of this study was to determine lipid peroxidation/antioxidant activity in patients with AA and to determine its clinical significance. Methods Fifty non-obese patients with AA and 50 age-, gender- and body mass index-matched controls (25 patients with severe grade acne vulgaris representative of an oxidative stress condition and 25 healthy volunteers), were included. Levels of malondialdehyde (MDA), indicator of lipid peroxidation and antioxidant activity of superoxide dismutase (SOD), were spectrophotometrically measured in blood from all subjects and in scalp tissues from 10 patients with AA. Results No significant differences in MDA levels and SOD activity existed between patients with AA and those with acne. However, significantly higher MDA levels and lower SOD activity were found in patients with AA compared with healthy controls. Within patients with AA, lipid peroxidation/antioxidant parameters showed significant differences with disease duration, pattern and extent of lesions. Significant positive correlations also existed between tissue and blood SOD activity and between tissue and blood MDA levels of the 10 studied patients with AA. Conclusions Increased lipid peroxidation and defective SOD activity exist in patients with AA. Addition of drugs with antioxidative effects seems to be valuable in treatment.
hair loss blog
20/07: Hair loss treatment
Treatment of Hair Loss at the Proctor Clinic.
09/07: Hair loss treatment
Hair Loss Treatment at the Proctor Clinic
01/05: Vitamin D and Hair loss
Dermatol Online J. 2010 Feb 15;16(2):3.
Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
Amor KT, et al
Exerpts
Vitamin D is a steroid hormone that is synthesized in the epidermal keratinocytes under influence of UV-B light (290-315 nm) or acquired in the diet and dietary supplements. Vitamin D needs both 25- and 1-alpha-hydroxylation to become the active hormone 1,25-dihydroxyvitamin D [1]. It is estimated that approximately 3 percent of the human genome is regulated directly or indirectly by the vitamin D endocrine system [1]. The vitamin D receptor (VDR), a nuclear hormone receptor, can up regulate or down regulate gene transcription in both a 1,25-dihydroxyvitamin D dependent and a 1,25-dihydroxyvitamin D independent fashion [2]. As such, the impact of vitamin D on human physiology and disease is broad and there is wide interest in the role of this hormone in many areas of medicine. New research demonstrating a high percentage of vitamin D deficiency or insufficiency in the population has sparked debate and controversy as to whether various disorders such as melanoma, premature aging, and cardiac disease among others can be correlated with inadequate vitamin D .
Within the field of dermatology, the role of vitamin D in the proliferation and differentiation of keratinocytes has been extensively studied and well reviewed in the literature [6]. In addition, vitamin D analogs, such as calcitriol (a vitamin D3 analog), have been used clinically to treat psoriasis for almost a decade and there is extensive literature on their use and mechanism of action.
The purpose of this review is to examine the role of vitamin D in hair growth and the hair cycle; we discuss the possible implications of vitamin D in the clinical care of patients with hair disorders.
Hair regrowth and hair cycle
The formation of the hair follicle during embryogenesis requires reciprocal signaling between the epithelium and mesenchymal cells. The major epithelial-derived signaling molecules involved in the early stages of hair follicle morphogenesis include fibroblast growth factors (FGF), bone morphogenic proteins (BMP), and sonic hedgehog (SHH) [9, 10]. These signals result in elongation of the hair follicle in embryogenesis. The first hair cycle after birth is unique because it represents the completion of the embryological development of the hair follicle and it is not dependent on the factors required for the maintenance of the hair follicle postnatally . Therefore, deficiencies in factors required for maintenance of the hair cycle are not evident until the first hair is shed.
Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
Amor KT, et al
Exerpts
Vitamin D is a steroid hormone that is synthesized in the epidermal keratinocytes under influence of UV-B light (290-315 nm) or acquired in the diet and dietary supplements. Vitamin D needs both 25- and 1-alpha-hydroxylation to become the active hormone 1,25-dihydroxyvitamin D [1]. It is estimated that approximately 3 percent of the human genome is regulated directly or indirectly by the vitamin D endocrine system [1]. The vitamin D receptor (VDR), a nuclear hormone receptor, can up regulate or down regulate gene transcription in both a 1,25-dihydroxyvitamin D dependent and a 1,25-dihydroxyvitamin D independent fashion [2]. As such, the impact of vitamin D on human physiology and disease is broad and there is wide interest in the role of this hormone in many areas of medicine. New research demonstrating a high percentage of vitamin D deficiency or insufficiency in the population has sparked debate and controversy as to whether various disorders such as melanoma, premature aging, and cardiac disease among others can be correlated with inadequate vitamin D .
Within the field of dermatology, the role of vitamin D in the proliferation and differentiation of keratinocytes has been extensively studied and well reviewed in the literature [6]. In addition, vitamin D analogs, such as calcitriol (a vitamin D3 analog), have been used clinically to treat psoriasis for almost a decade and there is extensive literature on their use and mechanism of action.
The purpose of this review is to examine the role of vitamin D in hair growth and the hair cycle; we discuss the possible implications of vitamin D in the clinical care of patients with hair disorders.
Hair regrowth and hair cycle
The formation of the hair follicle during embryogenesis requires reciprocal signaling between the epithelium and mesenchymal cells. The major epithelial-derived signaling molecules involved in the early stages of hair follicle morphogenesis include fibroblast growth factors (FGF), bone morphogenic proteins (BMP), and sonic hedgehog (SHH) [9, 10]. These signals result in elongation of the hair follicle in embryogenesis. The first hair cycle after birth is unique because it represents the completion of the embryological development of the hair follicle and it is not dependent on the factors required for the maintenance of the hair follicle postnatally . Therefore, deficiencies in factors required for maintenance of the hair cycle are not evident until the first hair is shed.
21/03: Hair Loss and Hair Regrowth
Hair Loss Treatment And Hair Regrowth
Dr Proctor holds nine patents for hair loss treatment and hair regrowth agents.
Dr Proctor holds nine patents for hair loss treatment and hair regrowth agents.
01/01: List of hair loss blogs
List of Hair loss treatment blogs
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30/12: Hair loss treatment blogs
29/12: Hair loss
hair loss treatment and hair regrowth blog
